Reducose®

Overview

Elevated blood glucose levels after meals can pave the way for various health problems, including insulin resistance and type 2 diabetes. Managing postprandial blood glucose is important for maintaining metabolic health.

Reducose® is a proprietary water extract of mulberry leaf. In seven clinical studies, it has been shown to significantly lower blood glucose and the glycemic index of foods by inhibiting carbohydrate-digesting enzymes.

This action mimics the effects of diets rich in fiber and resistant starch: by delaying carbohydrate digestion in the upper small intestine, it reduces glucose absorption and lowers blood glucose and insulin responses.

After approximately one hour, it dissociates from the digestive enzymes, passes into the bloodstream and is excreted unmetabolized via the kidneys, thus leaving no impact on the gut microbiota.

Key features

Reducose® 5%: A patented, premium white mulberry leaf extract.

Standardized content: Contains 4.5–5.5% 1-deoxynojirimycin (DNJ).

Blood glucose control: By inhibiting carbohydrate-breakdown enzymes, it is reported to reduce post-meal blood glucose and insulin spikes by up to 40%.

Natural and safe: Vegetarian, natural and allergen-free.

Proven efficacy: Supported by 7 human clinical studies.

Related publications:

Thondre P.S. et al. “Understanding the Impact of Different Doses of Reducose® Mulberry Leaf Extract on Blood Glucose and Insulin Responses after Eating a Complex Meal.” Nutrients 2024;16(11):1670.

Lee D. et al. “Glucose-lowering effect of Reducose® enriched with 1-deoxynojirimycin and L-leucine.” Heliyon 2024;10(3):e25499.

Ding F. et al. “The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread.” PLOS ONE 2023;18(8):e0288911.

Mohamed M. et al. Diabetes 2022;71(Suppl 1):41-LB.

Mechanism of action

Reducose® inhibits carbohydrate-digesting enzymes (alpha-glucosidase) in the upper small intestine. This inhibition delays carbohydrate digestion, reduces glucose absorption and lowers post-meal blood glucose and insulin responses.

This action mimics the effects of diets rich in fiber and resistant starch.

After approximately one hour, Reducose® dissociates from the digestive enzymes, passes into the bloodstream and is excreted unmetabolized via the kidneys. It is therefore reported to leave no impact on the gut microbiota.

Through inhibition of carbohydrate-breakdown enzymes, reductions of up to 40% in post-meal blood glucose and insulin spikes have been reported.