LiverDophilus®

Overview

LiverDophilus® is an evidence-based probiotic concept developed in collaboration with the Institute for Biological Research “Siniša Stanković” and the Institute of Molecular Genetics and Genetic Engineering (IMGGI).

The formulation is centered on the patented Lactobacillus helveticus strain, a scientifically characterized strain with documented potential to support liver health through modulation of the gut–liver axis.

Applications

LiverDophilus® is suitable for a broad range of food supplement and functional food applications.

Key features

The formulation is centered on the patented Lactobacillus helveticus strain. This strain has documented potential to support liver health through modulation of the gut–liver axis.

The strain has been investigated in preclinical models for its ability to reduce liver fat accumulation, influence metabolic pathways associated with steatosis, modulate systemic and hepatic inflammatory signaling and support intestinal barrier integrity. These functional properties align with the scientific interest in targeted probiotics for metabolic dysfunction-associated steatotic liver disease (MASLD).

The World Gastroenterology Organisation (WGO) Global Guidelines on Probiotics and Prebiotics (2023) highlight specific probiotic strains as beneficial in MASLD management (Level III evidence), supporting the relevance of the BGRA43 strain.

It is a patented, safe and scientifically substantiated solution, offering a biological, non-invasive approach for the growing liver health segment.

It is QPS-listed by EFSA, supporting its recognized safety for human use.

Mechanism of action

LiverDophilus® acts via the gut–liver axis.

The following effects of the patented Lactobacillus helveticus strain have been reported in preclinical models:

Reduction of high-fat diet–induced hepatic steatosis.

Preservation of hepatocyte morphology under metabolic stress.

Modulation of inflammatory cytokine signaling pathways — particularly TLR4-, TNF- and IL-1-related pathways.

Normalization of gut microbial composition.

Enhancement of intestinal barrier function.

These effects are supported by studies demonstrating modulation of lipid metabolism, inflammatory pathways and intestinal barrier function.