Eldosamb®

Overview

Eldosamb® is a standardized black elderberry (Sambucus nigra) extract known for its immune-supporting properties.

Carefully selected berries, combined with an established production process, guarantee a minimum anthocyanin content of 13%.

A preclinical research program found that Eldosamb® exhibits immunomodulatory properties, balancing inflammatory immune responses by decreasing pro-inflammatory TNF-α and IFN-γ levels and increasing the anti-inflammatory cytokine IL-10. It has also been shown that elderberry constituents can moderately reduce virus infectivity.

Applications

Eldosamb® is suitable for food supplements as well as for food and beverage applications.

Key features

It is reported to decrease the pro-inflammatory cytokines TNF-α and IFN-γ.

It increases the anti-inflammatory cytokine IL-10.

It leads to a shift in the Th2 helper cell response.

It has been reported to exhibit antiviral bioactivity in preclinical studies.

It is reported to counterbalance the pro-inflammatory response during acute infections.

It has been shown to moderately reduce virus infectivity in the mouth and throat mucosa (MVA virus).

It is a highly standardized elderberry extract.

Related publications: Schön C. et al. “A new high-quality elderberry plant extract exerts antiviral and immunomodulatory effects in vitro and ex vivo.” Food and Agricultural Immunology, 2021;32(1). — Ren Y. et al. “Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.).” Molecules 2024;29(13):2971.

Mechanism of action

A preclinical research program found that Eldosamb® exhibits immunomodulatory properties.

It decreases levels of the pro-inflammatory cytokines TNF-α and IFN-γ and increases levels of the anti-inflammatory cytokine IL-10. This change contributes to balancing inflammatory immune responses and leads to a shift in the Th2 helper cell response.

It has also been shown that elderberry constituents can moderately reduce virus infectivity.